Zofran (Ondansetron) helps to relieve nausea and vomiting, especially when associated with the treatment of cancer (chemotherapy). Zofran may also be used to prevent or treat nausea and vomiting that occurs after surgery, and occasionally is used to treat severe vomiting during pregnancy.
What should I tell my doctor before I take Zofran?
They need to know if you have any of these conditions:
liver disease
an unusual or allergic reaction to ondansetron, granisetron, other medicines, foods, dyes, or preservatives
pregnant or trying to get pregnant
breastfeeding
How should I take Zofran?
Zofran pills are taken by mouth, refer to the directions below that match the type of tablets you were prescribed. Follow the directions on your prescription. Take your doses at regular intervals. Do not take Zofran more often than directed.
If you are taking Zofran to prevent nausea due to chemotherapy, the first dose of Zofran is usually given 30 minutes before chemotherapy, followed by a dose at regular intervals for one or two days after chemotherapy.
Contact your pediatrician regarding the use of Zofran in children. Special care may be needed.
What if I miss a dose?
If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.
What drugs may interact with Zofran?
bosentan
carbamazepine
cisplatin
cyclophosphamide
phenobarbital
phenytoin
rifabutin
rifampin
rifapentine
tramadol
Tell your doctor about all other medicines you are taking, including non-prescription medicines, nutritional supplements, or herbal products. Also tell your doctor if you are a frequent user of drinks with caffeine or alcohol, if you smoke, or if you use illegal drugs. These may affect the way your medicine works. Check with your health care professional before stopping or starting any of your medicines.
What side effects may I notice from taking ondansetron?
Side effects that you should report to your doctor as soon as possible:
difficulty breathing, wheezing, shortness of breath
fast or irregular heartbeat
fever and chills
tightness in the chest
skin rash, itching
swelling of the face, tongue, throat, hands and feet
Side effects that usually do not require medical attention (report to your doctor if they continue or are bothersome):
constipation or diarrhea
dry mouth
fainting or lightheadedness
headache
stomach pain
tiredness
What should I watch for while taking Zofran?
Check with your doctor as soon as you can if you have any sign of an allergic reaction.
Do not take alcohol while taking ondansetron.
Where can I keep Zofran?
Keep out of the reach of children. Store between 2 and 30 degrees C (36 and 86 degrees F). Throw away any unused medicine after the expiration date.
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